Analytical Immunoengineering Laboratory
* Co-first Authors
21. Mandal S, Melo M, Gordiichuk P, Acharya S, Poh Y, Li N, Aung A, Dane EL, Irvine DJ, Kumari S. "WASP facilitates tumor mechanosensitivity in T lymphocytes." eLife 12:RP91854. 2024.
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20. Aung A, Irvine DJ. "Modulating antigen availability in lymphoid organs to shape the humoral immune response to vaccines." Accepted. Journal of Immunology. 212 (2): 171–178. 2024.
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19. Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xia S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. “Low protease activity in B cell follicles promotes retention of intact antigens after immunization.” Science. 379(6630). 2023.
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18. Zhang AQ, Hostetler A, Chen LE, Mukkamala V, Abraham W, Padilla LT, Wolff AN, Maiorino L, Backlund CM, Aung A, Melo M, Li N, Wu S, Irvine DJ. “Universal redirection of chimeric antigen receptor T cells against solid tumors via tumor cell membrane-inserting CAR ligands.” Nature Biomedical Engineering. 7:1113-28. 2023.
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17. Aung A, Davey SK, Theprungsirikul J, Kumar V, Varghese S. “Deciphering the mechanics of cancer spheroid growth in 3D environments through microfluidics driven mechanical actuation”. Advanced Healthcare Materials. (2022).
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16. Read BJ, Won L, Kraft JC, Sappington I, Aung A, Wu S, Bals J, Chen C, Lee KK, Lingwood D, King NP, Irvine DJ. “Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens”. Cell Reports. 38(2): 110217. 2022.
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15. Wang C, Cui A, Bukenya M, Aung A, Thomas A, Liang S, Suh H, Spranger S, Hacohen N, Irvine DJ. “Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade”. Cell Reports. 37(8): 110021. 2021.
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14. Silva M, Kato Y, Melo MB, Phung I, Freeman, BL, Li Z, Roh K, Wijbergern, JV, Watkins H, Enemuo CA, Hartwell B, Chang J, Xiao S, Rodrigues K, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Kataria S, Bastidas R, Bhinman J, Linde C, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton D, Alter G, Padera T, Belcher A, Schief WR, Silvestri G, Ruprecht R, Crotty S, Irvine DJ. “A potent saponin and TLR agonist particulate vaccine adjuvant alters lymphatic flow and lymph node antigen accumulation.” Science Immunology. 6(66):eabf1151. 2021.
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13. Irvine DJ, Aung A, Silva M. “Controlling timing and location in vaccines.” Adv. Drug Deliver. Rev. 158: 91-115. 2020.
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12. Aung A, Kumar V, Theprungsirikul J, Davey SK, Varghese S. “Engineered tumor-on-a-chip device with cancer-immune interactions for assessing T-cell recruitment”. Cancer Research. 80 (2): 263-275. 2020.
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11. Serrano R, Aung A, Yeh Y, Varghese S, Lasheras JC, del Alamo, JC. “Three-dimensional monolayer stress microscopy.” Biophysical Journal. 116: 1-18. 2019.
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10. Agrawal G*, Aung A*, Varghese S. “Assessing maturation of engineered skeletal muscle in perfused microfluidics environment.” Lab on a Chip. 17(20): 3447-3461. 2017.
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9. Aung A, Theprungsirikul J, Lim HL, Varghese S. “Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.” Lab on a Chip. 16(10): 1886-98. 2016.
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8. Aung A*, Bhullar I*, Theprungsirikul J, Davey SK, Lim HL, Chiu Y, Ma X, Dewan S, Lo Y, McCulloch A, Varghese S. “3D cardiac µtissues within microfluidics device with real-time contractile force read out.” Lab on a Chip. 16: 153-162. 2016.
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7. Davey SK*, Aung A*, Agrawal G, Lim HL, Kar M, Varghese S. “Embedded 3D photo-patterning of hydrogels with diverse and complex architectures for tissue engineering and disease models.” Tissue Engineering: Part C. 21(11): 1188-1196. 2015.
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6. Aung A, Seo YN, Lu S, Wang Y, Jamora C, del Alamo JC, Varghese S. “3D Traction stresses activate protease-dependent invasion of cancer cells.” Biophysical Journal. 107 (11): 2538-37. 2014.
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5. Caro-Diaz EJE, Aung A, Xu J, Varghese S, Theodorakis EA. “Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors.” Organic Chemistry Frontiers. 1(2): 135-39. 2014.
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4. Aung A*, Gupta G*, Majid G, Varghese S. “Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenschymal stem cells.” Arthritis & Rheumatology. 63 (1): 148-58. 2011.
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3. Ayala R, Zhang C, Yang D, Hwang Y, Aung A, Shroff SS, Arce FT, Lal R, Arya G, Varghese S. “Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation.” Biomaterials. 32 (15): 3700-11. 2011.
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2. Lim HL, Chuang JC, Tran T, Aung A, Arya G, Varghese S. “Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture.” Advanced Functional Materials. 21 (1): 55-63. 2011.
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1. Zhang C, Aung A, Liao L, Varghese S. “A novel single precursor-based biodegradable hydrogel with enhanced mechanical properties.” Soft Matter. 5 (20): 3831-34. 2009.